In: Arch Invest Med (Mex) (1989 Apr-Jun) 20 (2): 197-201 ISSN: 0066-6769 (Published in Spanish)To assess the relationship between the doses of Opuntia and its acute hypoglycemic action in diabetics, eight patients with type II diabetes mellitus were studied. Four tests were performed to each patient with the intake of: (a) 400 ml of water, (b) 100 g (c) 300 g and (d) 500 g of broiled stems of Opuntia. Serum glucose was measured at 1, 60, 120 and 180 minutes. Maximal decrease of serum glucose was noticed at 180 minutes, with a mean of 2.3, 10, 30.1 and 46.7 mg/dl less than basal value with 1, 100, 300 and 500 g respectively (P=NS, less than 0.05 less than 0.001 and less than 0.001 respectively). A significant direct correlation (r = .0590, P less than 0.001) was noticed between the doses and the hypoglycemic effect.